|Research, Genetic Research, Genetic Testing|
Molecular-biological and genetic research into the causes, diagnosis and treatment of a whole range of diseases such as cancer or hereditary disorders is a major element in the activities of university hospitals. Genes contain the blueprints for all cells and organs in the human body. Changes (e.g. mutations) in these genes can contribute to the development of a multitude of diseases. The decoding of these genes and their changes has already lead to a better early diagnosis and treatment of certain diseases.
on the Pancreatic Cancer
More effective therapies due to research
Survival chances in cases of pancreatic cancer
are very low and the disease has been on the rise in recent years. Continually
improved methods of diagnosis have lead to successes in detecting the
disease earlier and in more patients. Pancreatic cancer is a highly
aggressive disease and comes in 5th place on death statistics of malignant
for a cure:
Molecular-biological studies on human pancreatic cancer cells in the 80s emphasised the importance of the role of growth factors (factors which accelerate growth in various cells, but mainly cancer cells) in the development of pancreatic cancer. These accelerate the growth of a range of cells and in particular cancer cells and are found in markedly increased numbers in pancreatic cancer. It has also been observed that factors which normally inhibit the growth of cells or lead to cell death are either found in lower numbers or have been impaired in their function by genetic changes. These factors therefore can no longer slow the growth of the pancreatic cancer cells.
In addition cancer cells produce factors, which enhance their own ability to invade the surrounding healthy, tissue and other organs and form secondary tumours (metastases).
increased presence of growth factors and a host of other molecular changes
give pancreatic cancer cells a considerable growth advantage, which
enhances the progress of the disease and which could be responsible
for the failure of the tumour to respond to chemotherapy or radiotherapy.
In the meantime a range of studies has been able to show that an increasingly
aggressive behaviour of pancreatic cancer and a shorter post-operative
life expectancy is linked to molecular change in the cancer cells. Understanding
these processes will possibly lead to effective medication.
Center also focuses on research into genetic defects in patients with
a family history of pancreatic cancer, as well as the inherited form
database for Prediction
|Research on the|
|Chance for a Cure|
|More effective Therapies|
|A Database for Prediction|