|Above: Pancreas transplantation. In the middle one can see the transplanted Pancreas (marked with little lines).|
Young, insulin-dependent sufferers of Diabetes mellitus
can be afflicted with a number of conditions, caused by a malfunctioning
metabolism, such as rhenal failure, blindness, extensive damage to nervous
system and arteries with severe consequences for the blood supply to
the heart, brain or extremities. This disease is caused by the destruction
of insulin-producing islet cells in the pancreas. Glucose metabolised
through the intake of food cannot enter body cells in the absence of
insulin. This will cause multiple cell function failure.
As a treatment for Diabetes mellitus Type I, insulin must therefore be injected at regular intervals to ensure near-normal blood glucose levels. If levels cannot be maintained, damage as described above and additional conditions will be the outcome. Long-term damage is likely to occur.
This vicious cycle can be arrested
and reversed by a combined pancreas and kidney transplant, which will
eliminate both rhenal failure and establish a normal glucose metabolism.
A pancreas transplant only (without kidney) can be beneficial in exceptional
There is no need to transplant patients who do not suffer from diabetes-induced conditions and can keep their blood sugar at normal levels.
|When is a Pancreas Transplantation|
|Increased survival chances|